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The show focuses on "life, death, and drama at 20,000 feet," weaving together several major story arcs: "SkyMed" Has Freak Accidents and A LOT of Queer Characters

The "good story" behind is that it is loosely based on the real-life experiences of creator Julie Puckrin’s sister and brother-in-law, who met while working for an air ambulance service in Canada's North .

The series follows the high-stakes personal and professional lives of young nurses and pilots who operate medevac flights in remote Northern Manitoba. Core Narrative & Themes