MSMC and its successors remain vital tools for genomic research, providing a high-resolution view of human diversification. By modeling the drift and migration of our ancestors, these tools help clarify the demographic processes at the root of major historical transitions.
: Execute the software to estimate coalescence rates. Download MSMC Maps from Here (Click on this text)
: The model requires several input files, typically one per chromosome, containing segregating sites and information on "called" sites. MSMC and its successors remain vital tools for
: By comparing coalescence rates within and across pairs of populations, MSMC-IM can track how and when groups diverged. typically one per chromosome
) : The primary purpose of MSMC is to estimate the inverse of the coalescence rate, which can be interpreted as the Necap N sub e over time.