: Exposure and outcome are measured in the same group of people.
MR uses genetic variants as "natural experiments" to determine if an exposure (like high blood pressure) truly causes a disease (like stroke), rather than just being associated with it. ⚖️ The Three Pillars of MR Validity
: When a gene affects multiple traits independently, potentially biasing the causal estimate. Diseases - Mr Validity
This is for informational purposes only. For medical advice or diagnosis, consult a professional. AI responses may include mistakes. Learn more A Guide to Understanding Mendelian Randomization Studies
: Occurs if the chosen genetic variant is only weakly linked to the exposure, leading to inaccurate results. : Exposure and outcome are measured in the
: Typically single nucleotide polymorphisms (SNPs) identified through Genome-Wide Association Studies (GWAS) . Data Types :
For an MR report to be considered valid, it must demonstrate that the genetic instruments (SNPs) meet these criteria: This is for informational purposes only
: Differences in ancestry within a study can create false associations. 🛠️ Related Tools & Models