B cell subsets and certain antibodies like IgG1 show significant fluctuations based on the time of year.
Factors such as cohabitation, smoking, and cytomegalovirus (CMV) infection significantly alter immune composition. CMV alone can affect over 50% of immune parameters in an individual. Determining the expected variability of immune ...
Studies using high-dimensional flow cytometry and single-cell sequencing show that "healthy" ranges are broader than traditionally thought: B cell subsets and certain antibodies like IgG1
The human "immunotype" is shaped by a complex interplay of heritable and non-heritable factors: Expected Variation in Healthy Adults The most potent
Most immune variation is driven by life experiences and environmental exposures.
Heritability plays a more pronounced role in T cell populations compared to B cells , which are more susceptible to environmental cues. Specific genetic variants (ccQTLs) have been identified that regulate leukocyte counts and contribute to disease susceptibility. Expected Variation in Healthy Adults
The most potent intrinsic driver, causing a shift from precursor-biased (naïve) status to an inflammation-biased status.